An extracellular matrix paradox in myocardial scar formation
نویسندگان
چکیده
منابع مشابه
Myocardial extracellular matrix: an ever-changing and diverse entity.
The cardiac extracellular matrix (ECM) is a complex architectural network consisting of structural and nonstructural proteins, creating strength and plasticity. The nonstructural compartment of the ECM houses a variety of proteins, which are vital for ECM plasticity, and can be divided into 3 major groups: glycoproteins, proteoglycans, and glycosaminoglycans. The common denominator for these gr...
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INTRODUCTION MRL is a strain of mice with the unusual ability to recover from injuries without forming scar tissue. It was recently reported that the MRL mice can recover with little or no scar formation following a cryogenically induced myocardial infarction of the right ventricle. These findings suggest that scarless recovery from myocardial injury is possible in mammalian ventricles. If appl...
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BACKGROUND The extracellular matrix plays an important role in tissue regeneration. We investigated whether extracellular matrix protein fragments could be targeted with antibodies to ischemically injured myocardium to promote angiogenesis and myocardial repair. METHODOLOGY/PRINCIPAL FINDINGS Four peptides, 2 derived from fibronectin and 2 derived from Type IV Collagen, were assessed for in v...
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The armament of neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as neutrophil extracellular traps (NETs). The receptor/ligand interactions and intracellular signaling mechanisms responsible for elaborating NETs were determined for the response to Candida albicans. Because the host response of extravasated neutrophils t...
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1. Woywodt A, Haubitz M, Haller H, Matteson EL: Wegener’s granulomatosis. Lancet 367: 1362–1366, 2006 2. Klinger H: Grenzformen der Periarteriitis Nodosa. Frankf Z Pathol 42: 455–480, 1931 3. Wegener F: Ueber generalisierte septische Gefäßerkrankungen. Verh Deut Pathol Ges 29: 202–210, 1936 4. Wegener F: Ueber eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensyste...
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ژورنال
عنوان ژورنال: Signal Transduction and Targeted Therapy
سال: 2020
ISSN: 2059-3635
DOI: 10.1038/s41392-020-00270-z